Dataset Information
Ena-DATASET-VIB-08-06-2015-13:42:05:930-599 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001391 | EGA |
REPOSITORIES: EGA
Publications
Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.
Oncotarget 20151101 34
Hepatic angiosarcoma is a rare and aggressive vascular neoplasm. Pathogenic driver mutations are largely unknown. We present the case of a patient with recurrent hepatic angiosarcoma, who initially showed good response to sunitinib, followed by progression. Using comprehensive molecular techniques, we explored the potential mechanisms of resistance. By low-read-depth whole-genome sequencing, the comparison of copy number aberrations (CNAs) of the primary tumor to the skin metastatic lesion that ...[more]
