Genomics

Dataset Information

0

Ena-DATASET-ICR-PTGT-28-07-2015-16:51:33:172-264 - samples


ABSTRACT: Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in TCF12 and in an additional series of 83 AO. Overall 7.5% of AO are mutated for TCF12, which encodes an oligodendrocyte-related transcription factor. 80% of TCF12 mutations identified were in either the bHLH domain, which is important for TCF12 function as a transcription factor, or were frame shift mutations leading to TCF12 truncated for this domain. We show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumor type. Our analysis provides further insights into the unique and shared pathways driving AO.

PROVIDER: EGAD00001001452 | EGA |

REPOSITORIES: EGA

altmetric image

Publications


Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in TCF12 and in an additional series of 83 AO. Overall, 7.5% of AO are mutated for TCF12, w  ...[more]

Similar Datasets

| EGAS00001001209 | EGA
2015-06-15 | E-MTAB-2767 | biostudies-arrayexpress
2015-07-23 | E-MTAB-2768 | biostudies-arrayexpress
2015-07-23 | E-MTAB-3457 | biostudies-arrayexpress
2015-06-15 | E-MTAB-2771 | biostudies-arrayexpress
2015-08-15 | E-MTAB-2772 | biostudies-arrayexpress
2015-07-23 | E-MTAB-3458 | biostudies-arrayexpress
2015-02-02 | E-MTAB-2833 | biostudies-arrayexpress
2021-11-16 | MSV000088396 | MassIVE
2013-10-17 | E-GEOD-44748 | biostudies-arrayexpress