Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001561 | EGA |
REPOSITORIES: EGA
Science (New York, N.Y.) 20140901 6204
Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations representing the major myeloid commitment stages and the main lymphoid stage. We identified extensive cell type-specific expression changes: 6711 genes and 10,724 transcripts, enriched in non-protein-coding elements at early stages of differentiation. In addition, we found 7 ...[more]