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Ena-DATASET-MGH2-10-11-2015-05:01:11:768-248 - samples

ABSTRACT: Whole genome sequences of ACC primagrafts, Histone modification maps and transcription factor binding maps for ACC primagrafts and primary tumors. Processed ChIP-seq data is available on GEO under accession number GSE76465.

PROVIDER: EGAD00001001662 | EGA |

REPOSITORIES: EGA

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Publications

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.

Drier Yotam Y Cotton Matthew J MJ Williamson Kaylyn E KE Gillespie Shawn M SM Ryan Russell J H RJ Kluk Michael J MJ Carey Christopher D CD Rodig Scott J SJ Sholl Lynette M LM Afrogheh Amir H AH Faquin William C WC Queimado Lurdes L Qi Jun J Wick Michael J MJ El-Naggar Adel K AK Bradner James E JE Moskaluk Christopher A CA Aster Jon C JC Knoechel Birgit B Bernstein Bradley E BE

Nature genetics 20160201 3

Translocation events are frequent in cancer and may create chimeric fusions or 'regulatory rearrangements' that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. Chromosome conformation capture confirms th ...[more]

PMID: 26829750

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