Dataset Information

Ena-DATASET-BGI-26-11-2015-07:58:13:440-13 - samples

ABSTRACT: Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. Meanwhile, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we show a comprehensive genomic analysis in 158 ESCC cases, as part of the International Cancer Genome Consortium (ICGC) Research Projects (http://icgc.org/icgc/cgp/72/371/1001734). We conducted whole-genome sequencing in 14 ESCC cases and whole-exome sequencing in 90 cases.

PROVIDER: EGAD00001001691 | EGA |

REPOSITORIES: EGA

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Publications

Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma.

Cheng Caixia C Cui Heyang H Zhang Ling L Jia Zhiwu Z Song Bin B Wang Fang F Li Yaoping Y Liu Jing J Kong Pengzhou P Shi Ruyi R Bi Yanghui Y Yang Bin B Wang Juan J Zhao Zhenxiang Z Zhang Yanyan Y Hu Xiaoling X Yang Jie J He Chanting C Zhao Zhiping Z Wang Jinfen J Xi Yanfeng Y Xu Enwei E Li Guodong G Guo Shiping S Chen Yunqing Y Yang Xiaofeng X Chen Xing X Liang Jianfang J Guo Jiansheng J Cheng Xiaolong X Wang Chuangui C Zhan Qimin Q Cui Yongping Y

GigaScience 20160111

<h4>Background</h4>Esophageal squamous cell carcinoma (ESCC) is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Genomic characterization of tumors, particularly those of different stages, is likely to reveal additional oncogenic mechanisms. Although copy number alterations and somatic point mutations associated with the development of ESCC have been identified by array-based technologies and genome-wide studies, the genomic characterization of ESCCs from differ ...[more]

PMID: 26759717

Dataset Information

Ena-DATASET-BGI-26-11-2015-07:58:13:440-13 - samples

Publications

Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma.

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