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Ena-DATASET-GR-05-12-2015-13:51:06:366-72 - samples

ABSTRACT: In this dataset are the data from : - 17 patients studied by WGS - 49 patients studied by WES - 9 (/49) patients studied by RNASeq at 2 time points - the same 9 patients studied by ERRBS at 2 time points

PROVIDER: EGAD00001001853 | EGA |

REPOSITORIES: EGA

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Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents.

Merlevede Jane J Droin Nathalie N Qin Tingting T Meldi Kristen K Yoshida Kenichi K Morabito Margot M Chautard Emilie E Auboeuf Didier D Fenaux Pierre P Braun Thorsten T Itzykson Raphael R de Botton Stéphane S Quesnel Bruno B Commes Thérèse T Jourdan Eric E Vainchenker William W Bernard Olivier O Pata-Merci Noemie N Solier Stéphanie S Gayevskiy Velimir V Dinger Marcel E ME Cowley Mark J MJ Selimoglu-Buet Dorothée D Meyer Vincent V Artiguenave François F Deleuze Jean-François JF Preudhomme Claude C Stratton Michael R MR Alexandrov Ludmil B LB Padron Eric E Ogawa Seishi S Koscielny Serge S Figueroa Maria M Solary Eric E

Nature communications 20160224

The cytidine analogues azacytidine and 5-aza-2'-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a comprehensive analysis of the mutational landscape of these tumours, combining whole-exome and whole-genome se ...[more]

PMID: 26908133

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