Genomics

Dataset Information

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Ena-DATASET-CGNT-05-12-2015-13:59:52:975-75 - samples


ABSTRACT: Exome sequencing of nine PCC/PGL tumors, SF and FFPE samples

PROVIDER: EGAD00001001854 | EGA |

REPOSITORIES: EGA

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Publications

Malignant pheochromocytomas/paragangliomas harbor mutations in transport and cell adhesion genes.

Wilzén Annica A   Rehammar Anna A   Muth Andreas A   Nilsson Ola O   Tešan Tomić Tajana T   Wängberg Bo B   Kristiansson Erik E   Abel Frida F  

International journal of cancer 20151230 9


One out of ten patients with pheochromocytoma (PCC) and paraganglioma (PGL) develop malignant disease. Today there are no reliable pathological methods to predict malignancy at the time of diagnosis. Tumors harboring mutations in the succinate dehydrogenase subunit B (SDHB) gene often metastasize but the sequential genetic events resulting in malignant progression are not fully understood. The aim of this study was to identify somatic mutations that contribute to the malignant transformation of  ...[more]

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