Genomics

Dataset Information

0

PCGP MB WGS Full - samples

ABSTRACT: DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)

PROVIDER: EGAD00001001864 | EGA |

REPOSITORIES: EGA

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Publications

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott Paul A PA   Lee Catherine C   Zichner Thomas T   Stütz Adrian M AM   Erkek Serap S   Kawauchi Daisuke D   Shih David J H DJ   Hovestadt Volker V   Zapatka Marc M   Sturm Dominik D   Jones David T W DT   Kool Marcel M   Remke Marc M   Cavalli Florence M G FM   Zuyderduyn Scott S   Bader Gary D GD   VandenBerg Scott S   Esparza Lourdes Adriana LA   Ryzhova Marina M   Wang Wei W   Wittmann Andrea A   Stark Sebastian S   Sieber Laura L   Seker-Cin Huriye H   Linke Linda L   Kratochwil Fabian F   Jäger Natalie N   Buchhalter Ivo I   Imbusch Charles D CD   Zipprich Gideon G   Raeder Benjamin B   Schmidt Sabine S   Diessl Nicolle N   Wolf Stephan S   Wiemann Stefan S   Brors Benedikt B   Lawerenz Chris C   Eils Jürgen J   Warnatz Hans-Jörg HJ   Risch Thomas T   Yaspo Marie-Laure ML   Weber Ursula D UD   Bartholomae Cynthia C CC   von Kalle Christof C   Turányi Eszter E   Hauser Peter P   Sanden Emma E   Darabi Anna A   Siesjö Peter P   Sterba Jaroslav J   Zitterbart Karel K   Sumerauer David D   van Sluis Peter P   Versteeg Rogier R   Volckmann Richard R   Koster Jan J   Schuhmann Martin U MU   Ebinger Martin M   Grimes H Leighton HL   Robinson Giles W GW   Gajjar Amar A   Mynarek Martin M   von Hoff Katja K   Rutkowski Stefan S   Pietsch Torsten T   Scheurlen Wolfram W   Felsberg Jörg J   Reifenberger Guido G   Kulozik Andreas E AE   von Deimling Andreas A   Witt Olaf O   Eils Roland R   Gilbertson Richard J RJ   Korshunov Andrey A   Taylor Michael D MD   Lichter Peter P   Korbel Jan O JO   Wechsler-Reya Robert J RJ   Pfister Stefan M SM  

Nature 20140622 7510

Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we de  ...[more]

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