Ena-DATASET-MED-DUS-26-07-2016-11:14:36:814-193 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001002262 | EGA |
REPOSITORIES: EGA
Publications
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
Joosten Maria M Ginzel Sebastian S Blex Christian C Schmidt Dmitri D Gombert Michael M Chen Cai C Linka René Martin RM Gräbner Olivia O Hain Anika A Hirsch Burkhard B Sommerfeld Anke A Seegebarth Anke A Gruber Uschi U Maneck Corinna C Zhang Langhui L Stenin Katharina K Dieks Henrik H Sefkow Michael M Münk Carsten C Baldus Claudia D CD Thiele Ralf R Borkhardt Arndt A Hummel Michael M Köster Hubert H Fischer Ute U Dreger Mathias M Seitz Volkhard V
Molecular oncology 20160609 8
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or relapsed B-cell lymphoma achieved partial or complete remissions. Therefore, the purpose of this study was to identify molecular features that predict the response of B-cell lymphomas to SAHA treatment. We designed an integrative approach combining drug efficacy testing with exome and ca ...[more]
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