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Ena-DATASET-MOMA-03-11-2016-12:51:38:180-589 - samples

ABSTRACT: In this study we characterized genomic alterations in three bladder cancer patients with metastatic disease courses. Multiple regions were procured by laser microdissection or punctures from primary tumor, lymph node metastases and from distant metastases. Data provided here consist of 35 Bam files for WES (32 Tumors and 2 blood, 1 adjacent normal)

PROVIDER: EGAD00001002772 | EGA |

REPOSITORIES: EGA

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Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma.

Thomsen Mathilde B H MB Nordentoft Iver I Lamy Philippe P Høyer Søren S Vang Søren S Hedegaard Jakob J Borre Michael M Jensen Jørgen B JB Ørntoft Torben F TF Dyrskjøt Lars L

Molecular oncology 20160817 9

Patients with metastatic bladder cancer have a median survival of only 13-14 months. Precision medicine using targeted therapy may improve survival. Here we investigated spatial and temporal tumour evolution and tumour heterogeneity in order to evaluate the potential use of targeted treatment of metastatic bladder cancer. We performed a proof-of-concept study by whole exome sequencing of multiple tumour regions (n = 22) from three patients with metastatic bladder cancer. DNA from primary and met ...[more]

PMID: 27582092

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