Dataset Information
Ena-DATASET-MPIMG-15-06-2017-11:25:35:352-1374 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001003381 | EGA |
REPOSITORIES: EGA
Publications
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Nature communications 20170210
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large bio ...[more]