Dataset Information
BRCA_SNV_SR - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001003753 | EGA |
REPOSITORIES: EGA
Publications
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.
Nature communications 20170109
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes and methylomes of localized PCa from 14 carriers of deleterious germline BRCA2 mutations (BRCA2-mutant PCa). We show that BRCA2-mutant PCa harbour increased genomic instability and a mutational profile that more closely resembles metastastic than localized dise ...[more]