Genomics

Dataset Information

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Ena-DATASET-NKI-26-03-2018-09:37:16:082-880 - samples

ABSTRACT: The dataset "RNA-seq colorectal adenomas NKI-AvL TGO series Gut2009" includes 2 x 32 fastq files from paired-end mRNA sequencing on Illumina HiSeq2500 for 32 snap-frozen colorectal adenomas.

OTHER RELATED OMICS DATASETS IN: PRJNA100903

PROVIDER: EGAD00001004058 | EGA |

REPOSITORIES: EGA

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Publications

Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression.

Carvalho B B   Postma C C   Mongera S S   Hopmans E E   Diskin S S   van de Wiel M A MA   van Criekinge W W   Thas O O   Matthäi A A   Cuesta M A MA   Terhaar Sive Droste J S JS   Craanen M M   Schröck E E   Ylstra B B   Meijer G A GA  

Gut 20081001 1

<h4>Objective</h4>This study aimed to identify the oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on mRNA expression of genes in this amplicon.<h4>Methods</h4>Segmentation of DNA copy number changes on 20q was performed by array CGH (comparative genomic hybridisation) in 34 non-progressed colorectal adenomas, 41 progressed adenomas (ie, adenomas that present a focus of cancer) and 33 adenocarcinomas. Moreover, a robust analysis of alt  ...[more]

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