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273ad39f-3094-4126-a10e-96c1321a07fb - samples

ABSTRACT: FastQ files with paired-end RNAseq data for human fetal brain homogenate from 120 samples (12-19 post-conception weeks).

PROVIDER: EGAD00001004363 | EGA |

REPOSITORIES: EGA

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Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.

O'Brien Heath E HE Hannon Eilis E Hill Matthew J MJ Toste Carolina C CC Robertson Matthew J MJ Morgan Joanne E JE McLaughlin Gemma G Lewis Cathryn M CM Schalkwyk Leonard C LC Hall Lynsey S LS Pardiñas Antonio F AF Owen Michael J MJ O'Donovan Michael C MC Mill Jonathan J Bray Nicholas J NJ

Genome biology 20181112 1

<h4>Background</h4>Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies that have mapped genome-wide expression quantitative trait loci (eQTL) specifically in the human prenatal brain.<h4>Results</h4>We performed deep RNA sequencing and genome-wide genotyping on a unique collection of 120 human brains from the second tri ...[more]

PMID: 30419947

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