Dataset Information
ICGC Oesophageal Adenocarcinoma sequence data - af_driver_paper_release - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001004417 | EGA |
REPOSITORIES: EGA
Publications
Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.
Nature genetics 20140622 8
Cancer genome sequencing studies have identified numerous driver genes, but the relative timing of mutations in carcinogenesis remains unclear. The gradual progression from premalignant Barrett's esophagus to esophageal adenocarcinoma (EAC) provides an ideal model to study the ordering of somatic mutations. We identified recurrently mutated genes and assessed clonal structure using whole-genome sequencing and amplicon resequencing of 112 EACs. We next screened a cohort of 109 biopsies from 2 key ...[more]
