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E8e237ad-12b0-4a8b-b547-b5cfe0904955 - samples

ABSTRACT: Exome sequencing of 317 rainforest hunter-gatherers (RHG) and neighbouring farmers (AGR) from Central Africa was performed based on the Nextera Rapid Capture Expanded Exome Kit (62-Mb content) with the Illumina HiSeq 2500. The population sample includes the Baka of south-eastern Cameroon and northern Gabon (wRHG), the Bantu-speaking Nzebi and Bapunu sedentary agriculturalists of Gabon (wAGR), and the BaTwa (eRHG) and BaKiga (eAGR) from Uganda. After QC filters, exomes of 300 unrelated individuals were obtained at high coverage (mean depth 68x), including 406,270 variants.

PROVIDER: EGAD00001004569 | EGA |

REPOSITORIES: EGA

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The demographic history and mutational load of African hunter-gatherers and farmers.

Lopez Marie M Kousathanas Athanasios A Quach Hélène H Harmant Christine C Mouguiama-Daouda Patrick P Hombert Jean-Marie JM Froment Alain A Perry George H GH Barreiro Luis B LB Verdu Paul P Patin Etienne E Quintana-Murci Lluís L

Nature ecology & evolution 20180312 4

Understanding how deleterious genetic variation is distributed across human populations is of key importance in evolutionary biology and medical genetics. However, the impact of population size changes and gene flow on the corresponding mutational load remains a controversial topic. Here, we report high-coverage exomes from 300 rainforest hunter-gatherers and farmers of central Africa, whose distinct subsistence strategies are expected to have impacted their demographic pasts. Detailed demograph ...[more]

PMID: 29531345

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971aec4a-5b25-4e45-8612-7dc2638168a5 - samples

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Genotyping of SNP array in individuals with San ancestry in southeastern Africa

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