Genomics

Dataset Information

0

04bf693b-1bf0-461f-914f-4b9f830af063 - samples


ABSTRACT: This case represented the genomic findings of a pediatric glioblastoma patient who underwent multiple surgical resections and treated with standard chemoradiation, as well as a novel recombinant poliovirus vaccine therapy. The results present the preservation of a STAG2 mutated clone, besides elimination and emergence of other clones with oncogenic mutations through disease progression under different treatment modalities. Although STAG2 deficiency comprises only a small subset of gliomas, this case adds clinical evidence to existing preclinical data supporting a role for STAG2 mutations in gliomagenesis and resistance to standard therapies.

PROVIDER: EGAD00001006202 | EGA |

REPOSITORIES: EGA

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