EGAS00001004124-sc-2020-08-20T12:51:31Z - samples
Ontology highlight
ABSTRACT: The hematological malignancy multiple myeloma (MM),
also called Kahler's disease or plasma cell (PC) myeloma, is
characterized by a clonal expansion of PCs originating in the
bone marrow (BM). The expansion of these cells leads to an
overproduction of antibodies and results in typical symptoms
such as anemia, renal failure and bone lesions. All cases of MM
are preceded by the asymptomatic, non-malignant pre-stage
monoclonal gammopathy of undetermined significance (MGUS). Of
all MGUS patients, only 1% per year will progress to MM. Despite
efforts to elucidate the molecular mechanisms underlying the
MGUS-to-MM progression, its pathogenesis still remains largely
unknown. Additionally, the genetic profiles of MGUS patients
have only been limitedly investigated due to the only incidental
finding of MGUS, the difficulties in BM sampling and isolating a
sufficient number of aberrant PCs from the BM aspirates of MGUS
patients. Consequently, reliable biomarkers to individually
predict which MGUS patients will progress to MM and which will
not, are lacking. Therefore, it is highly required to study the
molecular pathogenesis of MGUS and the role of genetic events in
relation to the malignant transformation to MM.
PROVIDER: EGAD00001006363 | EGA |
REPOSITORIES: EGA
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