Genomics

Dataset Information

0

Bd22328b-e147-4bec-8210-2824a108a846 - samples


ABSTRACT: This dataset consists of 60 mRNA sequencing runs from full blood of 31 myotonic dystrophy type 1 patients, of which for 27 patients reliable data is available before and after 10 months of cognitive behavioural therapy. >30 million 150 bp paired end reads were obtained with UMI-labeled adapters to facilitate filtering of PCR duplicates. Via UMI-analysis we found samples with the aliases sample_01 and sample_02 to contain a very high number of PCR duplicates and recommend the use of these samples only with highest caution or not at all.

PROVIDER: EGAD00001008383 | EGA |

REPOSITORIES: EGA

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Publications


<h4>Background</h4>Myotonic dystrophy type 1 is the most common form of muscular dystrophy in adults and leads to severe fatigue, substantial physical functional impairment, and restricted social participation. In this study, we aimed to determine whether cognitive behavioural therapy optionally combined with graded exercise compared with standard care alone improved the health status of patients with myotonic dystrophy type 1.<h4>Methods</h4>We did a multicentre, single-blind, randomised trial,  ...[more]

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