Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

68ec0468-04cd-43a5-aa90-bac6a79a6d14 - samples

ABSTRACT: Bank of treateed and control PDXs metastastic colorectal cancer sample RNAseq

PROVIDER: EGAD00001010022 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Similar Datasets

Treated and control Patient Derived Xenografts of colorectal cancer (CRC) samples

Project description:Bank of treateed and control PDXs metastastic colorectal cancer sample RNAseq

| EGAS00001006973 | EGA

5a61d481-b701-4bf7-8f90-34536ea1a38d - samples

Project description:Bank of metastatic colorectal cancer (mCRC) of Patient Derived Xenografts (PDXs)

| EGAD00001009171 | EGA

7b673a55-05fc-4e32-8926-60a98fb48139 - samples

Project description:Bank of primary sites (PRs) colorectal cancer of Patient Derived Xenografts (PDXs)

| EGAD00001010101 | EGA

dd2ed193-2af3-43ee-b51a-8415809635aa - samples

Project description:Bank of human both primary and metastastic colorectal cancer sample RNAseq

| EGAD00001009712 | EGA

RNAseq analysis on metastatic Colorectal Cancer xenografts samples

Project description:Bank of metastatic colorectal cancer (mCRC) of Patient Derived Xenografts (PDXs)

| EGAS00001006492 | EGA

RNAseq analysis on primary sites Colorectal Cancer xenografts (PRX) samples

Project description:Bank of primary sites (PRs) colorectal cancer of Patient Derived Xenografts (PDXs)

| EGAS00001007051 | EGA

Human primary and metastatic colorectal cancer (CRC) samples

Project description:Bank of human both primary and metastastic colorectal cancer sample RNAseq

| EGAS00001006746 | EGA

RNAseq analysis on metastatic Colorectal Cancer

Project description:In this study we want present a bank of metastatic colorectal cancer (mCRC) Patient Derived Organoids (PDOs) obtained from Patient Derived Xenografts (PDXs). These models are annotated with different omics to advance our understanding of CRC. We wanted to create a resource for the scientific community to assess the predictive reliability of these preclinical models. We performed comparative analyses between PDOs and matched PDXs to assess the similarities of these two platforms regarding molecular profiles and transcriptional classification. Moreover, we analyzed how these models respond to Cetuximab, a chimeric monoclonal antibody, normally given to patients after chemotherapy, that inhibits EGFR. After having assessed models’ reliability with Cetuximab, we aimed at identifying potential synergistic drugs to individuate new possible therapeutic prospects.

2023-03-01 | GSE204805 | GEO

CRIS, a superior predictive and prognostic classification system of colorectal cancer based on high-resolution analysis of cancer cell-autonomous traits II

Project description:Recent work built on published transcriptional subtypes of colorectal cancer (CRC) has shown that tumor stromal content impacts CRC classification, with both clinical and biological implications. To Tackle the issue of intrinsic epithelial gene profiles, we assembled a dataset of matched liver metastatic colorectal cancer and Patients Derived Xenografts. in which the stroma of the original tumor is substituted by murine tissue, we deployed a molecularly annotated collection of 515 PDXs from 244 patients as a resource for species (human)-specific assessment of cancer-cell intrinsic transcriptional features. We identified five ColoRectal cancer Intrinsic Subtypes (CRIS) endowed with functional and phenotypic characteristics related to specific genetic traits, most of which were not evidenced in the transcriptional subgroups reported in previous studies.

2017-06-19 | GSE76402 | GEO

CRIS, a superior predictive and prognostic classification system of colorectal cancer based on high-resolution analysis of cancer cell-autonomous traits

2017-06-19 | GSE73255 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data