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7ee82b15-ee1d-476e-b9ee-c2ede746cc52 - samples

ABSTRACT: Throughout an individualÃ¢Â€Â™s lifetime, genomic alterations accumulate in somatic cells. However, the mutational landscape induced by retrotransposition of long interspersed nuclear element-1 (L1), a widespread mobile element in the human genome, is poorly understood in normal cells. Here, we explored the whole-genome sequences of 406 normal colorectal clones, 12 MUTYH-associated adenomatous clones, and 19 matched colorectal cancer tissues. In addition, we analyzed promoter DNA methylation status of retrotransposition-competent L1 (in 139 clones) and read-through RNA expression profiles (in 116 clones) to investigate the epigenetic regulation of L1 activity.

PROVIDER: EGAD00001010183 | EGA |

REPOSITORIES: EGA

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Project description:Somatic L1 Retrotransposition of Colorectal Tumors

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Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

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