Genomics

Dataset Information

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PS

ABSTRACT: Psoriasis cases as part of WTCCC2 phase 2

PROVIDER: EGAD00010000124 | EGA |

REPOSITORIES: EGA

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Publications

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Strange Amy A   Capon Francesca F   Spencer Chris C A CC   Knight Jo J   Weale Michael E ME   Allen Michael H MH   Barton Anne A   Band Gavin G   Bellenguez Céline C   Bergboer Judith G M JG   Blackwell Jenefer M JM   Bramon Elvira E   Bumpstead Suzannah J SJ   Casas Juan P JP   Cork Michael J MJ   Corvin Aiden A   Deloukas Panos P   Dilthey Alexander A   Duncanson Audrey A   Edkins Sarah S   Estivill Xavier X   Fitzgerald Oliver O   Freeman Colin C   Giardina Emiliano E   Gray Emma E   Hofer Angelika A   Hüffmeier Ulrike U   Hunt Sarah E SE   Irvine Alan D AD   Jankowski Janusz J   Kirby Brian B   Langford Cordelia C   Lascorz Jesús J   Leman Joyce J   Leslie Stephen S   Mallbris Lotus L   Markus Hugh S HS   Mathew Christopher G CG   McLean W H Irwin WH   McManus Ross R   Mössner Rotraut R   Moutsianas Loukas L   Naluai Asa T AT   Nestle Frank O FO   Novelli Giuseppe G   Onoufriadis Alexandros A   Palmer Colin N A CN   Perricone Carlo C   Pirinen Matti M   Plomin Robert R   Potter Simon C SC   Pujol Ramon M RM   Rautanen Anna A   Riveira-Munoz Eva E   Ryan Anthony W AW   Salmhofer Wolfgang W   Samuelsson Lena L   Sawcer Stephen J SJ   Schalkwijk Joost J   Smith Catherine H CH   Ståhle Mona M   Su Zhan Z   Tazi-Ahnini Rachid R   Traupe Heiko H   Viswanathan Ananth C AC   Warren Richard B RB   Weger Wolfgang W   Wolk Katarina K   Wood Nicholas N   Worthington Jane J   Young Helen S HS   Zeeuwen Patrick L J M PL   Hayday Adrian A   Burden A David AD   Griffiths Christopher E M CE   Kere Juha J   Reis André A   McVean Gilean G   Evans David M DM   Brown Matthew A MA   Barker Jonathan N JN   Peltonen Leena L   Donnelly Peter P   Trembath Richard C RC  

Nature genetics 20101017 11

To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). W  ...[more]

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