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ABSTRACT: Pharmacogenomic response to Statins samples (Genotypes/Phenotypes)

PROVIDER: EGAD00010000282 | EGA |

REPOSITORIES: EGA

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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Zhou Kaixin K Bellenguez Celine C Spencer Chris C A CC Bennett Amanda J AJ Coleman Ruth L RL Tavendale Roger R Hawley Simon A SA Donnelly Louise A LA Schofield Chris C Groves Christopher J CJ Burch Lindsay L Carr Fiona F Strange Amy A Freeman Colin C Blackwell Jenefer M JM Bramon Elvira E Brown Matthew A MA Casas Juan P JP Corvin Aiden A Craddock Nicholas N Deloukas Panos P Dronov Serge S Duncanson Audrey A Edkins Sarah S Gray Emma E Hunt Sarah S Jankowski Janusz J Langford Cordelia C Markus Hugh S HS Mathew Christopher G CG Plomin Robert R Rautanen Anna A Sawcer Stephen J SJ Samani Nilesh J NJ Trembath Richard R Viswanathan Ananth C AC Wood Nicholas W NW Harries Lorna W LW Hattersley Andrew T AT Doney Alex S F AS Colhoun Helen H Morris Andrew D AD Sutherland Calum C Hardie D Grahame DG Peltonen Leena L McCarthy Mark I MI Holman Rury R RR Palmer Colin N A CN Donnelly Peter P Pearson Ewan R ER

Nature genetics 20101226 2

Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.4 ...[more]

PMID: 21186350

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