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FinnuncorrNLITUK1UK3hap300_onlyNBS - samples

ABSTRACT: NBS control samples only (Hap300)

PROVIDER: EGAD00010000284 | EGA |

REPOSITORIES: EGA

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Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment.

Janssen Katja K Pohlmann Stephan S Jänicke Reiner U RU Schulze-Osthoff Klaus K Fischer Ute U

Blood 20070725 10

Taxane derivatives such as paclitaxel elicit their antitumor effects at least in part by induction of apoptosis, but the underlying mechanisms are incompletely understood. Here, we used different cellular models with deficiencies in key regulators of apoptosis to elucidate the mechanism of paclitaxel-induced cell death. Apoptosis by paclitaxel was reported to depend on the activation of the initiator caspase-10; however, we clearly demonstrate that paclitaxel kills murine embryonic fibroblasts ( ...[more]

PMID: 17652622

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