Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000560 | EGA |
REPOSITORIES: EGA
Iannelli Fabio F Collino Agnese A Sinha Shruti S Radaelli Enrico E Nicoli Paola P D'Antiga Lorenzo L Sonzogni Aurelio A Faivre Jamila J Buendia Marie Annick MA Sturm Ekkehard E Thompson Richard J RJ Knisely A S AS Natoli Gioacchino G Ghisletti Serena S Ciccarelli Francesca D FD
Nature communications 20140513
Hepatocellular carcinoma (HCC) is almost invariably associated with an underlying inflammatory state, whose direct contribution to the acquisition of critical genomic changes is unclear. Here we map acquired genomic alterations in human and mouse HCCs induced by defects in hepatocyte biliary transporters, which expose hepatocytes to bile salts and cause chronic inflammation that develops into cancer. In both human and mouse cancer genomes, we find few somatic point mutations with no impairment o ...[more]