Dataset Information

PCGP Ph-likeALL SNP6 - samples

ABSTRACT: PCGP Ph-likeALL SNP6

PROVIDER: EGAD00010000598 | EGA |

REPOSITORIES: EGA

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Publications

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Roberts Kathryn G KG Li Yongjin Y Payne-Turner Debbie D Harvey Richard C RC Yang Yung-Li YL Pei Deqing D McCastlain Kelly K Ding Li L Lu Charles C Song Guangchun G Ma Jing J Becksfort Jared J Rusch Michael M Chen Shann-Ching SC Easton John J Cheng Jinjun J Boggs Kristy K Santiago-Morales Natalia N Iacobucci Ilaria I Fulton Robert S RS Wen Ji J Valentine Marcus M Cheng Cheng C Paugh Steven W SW Devidas Meenakshi M Chen I-Ming IM Reshmi Shalini S Smith Amy A Hedlund Erin E Gupta Pankaj P Nagahawatte Panduka P Wu Gang G Chen Xiang X Yergeau Donald D Vadodaria Bhavin B Mulder Heather H Winick Naomi J NJ Larsen Eric C EC Carroll William L WL Heerema Nyla A NA Carroll Andrew J AJ Grayson Guy G Tasian Sarah K SK Moore Andrew S AS Keller Frank F Frei-Jones Melissa M Whitlock James A JA Raetz Elizabeth A EA White Deborah L DL Hughes Timothy P TP Guidry Auvil Jaime M JM Smith Malcolm A MA Marcucci Guido G Bloomfield Clara D CD Mrózek Krzysztof K Kohlschmidt Jessica J Stock Wendy W Kornblau Steven M SM Konopleva Marina M Paietta Elisabeth E Pui Ching-Hon CH Jeha Sima S Relling Mary V MV Evans William E WE Gerhard Daniela S DS Gastier-Foster Julie M JM Mardis Elaine E Wilson Richard K RK Loh Mignon L ML Downing James R JR Hunger Stephen P SP Willman Cheryl L CL Zhang Jinghui J Mullighan Charles G CG

The New England journal of medicine 20140901 11

<h4>Background</h4>Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.<h4>Methods</h4>We performed genomic profiling of 1725 patients with precursor ...[more]

PMID: 25207766

Publication: 1/2

Dataset Information

PCGP Ph-likeALL SNP6 - samples

Publications

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

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