Genomics

Dataset Information

0

Genentech gastric cell line sequencing - samples


ABSTRACT: SNP array data for gastric cancer cell lines

PROVIDER: EGAD00010000622 | EGA |

REPOSITORIES: EGA

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Publications


Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform exome and transcriptome sequencing and SNP array assays to characterize 51 primary gastric tumours and 32 cell lines. Meta-analysis of exome data and previously published data sets reveals 24 significantly mutated genes in microsatellite stable (MSS) tumours and 16 in microsatellite instable (MSI) tumours. Over half the patients in our collect  ...[more]

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