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610K_imputed - samples

ABSTRACT: 610k genotyping imputed on Hapmap 3 and 1000G Phase 1 CEU

PROVIDER: EGAD00010000704 | EGA |

REPOSITORIES: EGA

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A multi-factorial analysis of response to warfarin in a UK prospective cohort.

Bourgeois Stephane S Jorgensen Andrea A Zhang Eunice J EJ Hanson Anita A Gillman Matthew S MS Bumpstead Suzannah S Toh Cheng Hock CH Williamson Paula P Daly Ann K AK Kamali Farhad F Deloukas Panos P Pirmohamed Munir M

Genome medicine 20160106 1

<h4>Background</h4>Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.<h4>Methods</h4>A prospective cohort o ...[more]

PMID: 26739746

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