Dataset Information
PNG_GWAS-2.5M_b37_2019
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010001735 | EGA |
REPOSITORIES: EGA
Publications
A novel locus of resistance to severe malaria in a region of ancient balancing selection.
Nature 20150930 7572
The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major force for human evolutionary selection, but surprisingly few other polymorphisms have been proven to confer resistance to malaria in large epidemiological studies. To address this problem, we conducted a multi-centre genome-wide association study (GWAS) of life-threatening Plasmodium falciparum infection (severe malaria) in over 11,000 African children, with replication data in a further 14,000 individuals. H ...[more]