Genomics

Dataset Information

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PE-META-EUROPE-MATERNAL

ABSTRACT: Fixed effect meta-analysis summary statistics combining GWAS of maternal preeclampsia cases and controls from Europe (UK, Iceland, Norway, Denmark and Finland).

PROVIDER: EGAD00010001984 | EGA |

REPOSITORIES: EGA

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Publications

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Steinthorsdottir Valgerdur V   McGinnis Ralph R   Williams Nicholas O NO   Stefansdottir Lilja L   Thorleifsson Gudmar G   Shooter Scott S   Fadista João J   Sigurdsson Jon K JK   Auro Kirsi M KM   Berezina Galina G   Borges Maria-Carolina MC   Bumpstead Suzannah S   Bybjerg-Grauholm Jonas J   Colgiu Irina I   Dolby Vivien A VA   Dudbridge Frank F   Engel Stephanie M SM   Franklin Christopher S CS   Frigge Michael L ML   Frisbaek Yr Y   Geirsson Reynir T RT   Geller Frank F   Gretarsdottir Solveig S   Gudbjartsson Daniel F DF   Harmon Quaker Q   Hougaard David Michael DM   Hegay Tatyana T   Helgadottir Anna A   Hjartardottir Sigrun S   Jääskeläinen Tiina T   Johannsdottir Hrefna H   Jonsdottir Ingileif I   Juliusdottir Thorhildur T   Kalsheker Noor N   Kasimov Abdumadjit A   Kemp John P JP   Kivinen Katja K   Klungsøyr Kari K   Lee Wai K WK   Melbye Mads M   Miedzybrodska Zosia Z   Moffett Ashley A   Najmutdinova Dilbar D   Nishanova Firuza F   Olafsdottir Thorunn T   Perola Markus M   Pipkin Fiona Broughton FB   Poston Lucilla L   Prescott Gordon G   Saevarsdottir Saedis S   Salimbayeva Damilya D   Scaife Paula Juliet PJ   Skotte Line L   Staines-Urias Eleonora E   Stefansson Olafur A OA   Sørensen Karina Meden KM   Thomsen Liv Cecilie Vestrheim LCV   Tragante Vinicius V   Trogstad Lill L   Simpson Nigel A B NAB   Aripova Tamara T   Casas Juan P JP   Dominiczak Anna F AF   Walker James J JJ   Thorsteinsdottir Unnur U   Iversen Ann-Charlotte AC   Feenstra Bjarke B   Lawlor Deborah A DA   Boyd Heather Allison HA   Magnus Per P   Laivuori Hannele H   Zakhidova Nodira N   Svyatova Gulnara G   Stefansson Kari K   Morgan Linda L  

Nature communications 20201125 1

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q  ...[more]

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