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PDX_HTA2.0_Guergen2022

ABSTRACT: GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) and RCC metastases related to Guergen et al, Front Oncol 12:2022 889789. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.34.0). Probe sets were summarized on the Entrez GeneID level using the annotation provided by BrainArray (version 25).

PROVIDER: EGAD00010002392 | EGA |

REPOSITORIES: EGA

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Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.

Winter Stefan S Fisel Pascale P Büttner Florian F Rausch Steffen S D'Amico Debora D Hennenlotter Jörg J Kruck Stephan S Nies Anne T AT Stenzl Arnulf A Junker Kerstin K Scharpf Marcus M Hofmann Ute U van der Kuip Heiko H Fend Falko F Ott German G Agaimy Abbas A Hartmann Arndt A Bedke Jens J Schwab Matthias M Schaeffeler Elke E

Scientific reports 20160720

Current therapies for metastatic clear cell renal cell carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical cell line models during drug development, is influenced by pharmacogenes involved in targeting and disposition of drugs. Here we show through genome-wide DNA methylation profiling, that methylation patterns are concordant between primary ccRCC and macro-metastases irrespective of metastatic sites (rs ≥ 0.92). However, 195,038 (41%) of all investigat ...[more]

PMID: 27435027

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