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Omics score: 1006

The Type 1 Diabetes Genetics Consortium

ABSTRACT: The Type 1 Diabetes Genetics Consortium is a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. Its aim is to develop resources for the scientific community to identify genes influencing an individuals risk for developing Type 1 (juvenile onset) Diabetes (T1D).

PROVIDER: EGAO00000000012 | EGA |

REPOSITORIES: EGA

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Barrett Jeffrey C JC Clayton David G DG Concannon Patrick P Akolkar Beena B Cooper Jason D JD Erlich Henry A HA Julier Cécile C Morahan Grant G Nerup Jørn J Nierras Concepcion C Plagnol Vincent V Pociot Flemming F Schuilenburg Helen H Smyth Deborah J DJ Stevens Helen H Todd John A JA Walker Neil M NM Rich Stephen S SS

Nature genetics 20090510 6

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported association ...[more]

PMID: 19430480

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