Dataset Information

The International Cancer Genome Consortium

ABSTRACT: The International Cancer Genome Consortium (ICGC) has been organized to launch and coordinate a large number of research projects that have the common aim of elucidating comprehensively the genomic changes present in many forms of cancers that contribute to the burden of disease in people throughout the world. The primary goals of the ICGC are to generate comprehensive catalogues of genomic abnormalities (somatic mutations, abnormal expression of genes, epigenetic modifications) in tumors from 50 different cancer types and/or subtypes which are of clinical and societal importance across the globe and make the data available to the entire research community as rapidly as possible, and with minimal restrictions, to accelerate research into the causes and control of cancer. The ICGC facilitates communication among the members and provides a forum for coordination with the objective of maximizing efficiency among the scientists working to understand, treat, and prevent these diseases.

OTHER RELATED OMICS DATASETS IN: PRJNA213744PRJNA213380PRJNA214321

PROVIDER: EGAO00000000024 | EGA |

REPOSITORIES: EGA

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Publications

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Jones David T W DT Hutter Barbara B Jäger Natalie N Korshunov Andrey A Kool Marcel M Warnatz Hans-Jörg HJ Zichner Thomas T Lambert Sally R SR Ryzhova Marina M Quang Dong Anh Khuong DA Fontebasso Adam M AM Stütz Adrian M AM Hutter Sonja S Zuckermann Marc M Sturm Dominik D Gronych Jan J Lasitschka Bärbel B Schmidt Sabine S Seker-Cin Huriye H Witt Hendrik H Sultan Marc M Ralser Meryem M Northcott Paul A PA Hovestadt Volker V Bender Sebastian S Pfaff Elke E Stark Sebastian S Faury Damien D Schwartzentruber Jeremy J Majewski Jacek J Weber Ursula D UD Zapatka Marc M Raeder Benjamin B Schlesner Matthias M Worth Catherine L CL Bartholomae Cynthia C CC von Kalle Christof C Imbusch Charles D CD Radomski Sylwester S Lawerenz Chris C van Sluis Peter P Koster Jan J Volckmann Richard R Versteeg Rogier R Lehrach Hans H Monoranu Camelia C Winkler Beate B Unterberg Andreas A Herold-Mende Christel C Milde Till T Kulozik Andreas E AE Ebinger Martin M Schuhmann Martin U MU Cho Yoon-Jae YJ Pomeroy Scott L SL von Deimling Andreas A Witt Olaf O Taylor Michael D MD Wolf Stephan S Karajannis Matthias A MA Eberhart Charles G CG Scheurlen Wolfram W Hasselblatt Martin M Ligon Keith L KL Kieran Mark W MW Korbel Jan O JO Yaspo Marie-Laure ML Brors Benedikt B Felsberg Jörg J Reifenberger Guido G Collins V Peter VP Jabado Nada N Eils Roland R Lichter Peter P Pfister Stefan M SM

Nature genetics 20130630 8

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible midline tumors are therapeutically challenging, showing sustained tendency for progression and often becoming a chronic disease with substantial morbidities. Here we describe whole-genome sequencing of 96 pilocytic astrocytomas, with matched RNA sequencing (n = 73), conducted by the International Cancer Genome Consortium ( ...[more]

PMID: 23817572

Publication: 1/31

Dataset Information

The International Cancer Genome Consortium

Publications

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

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