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Barts and The London School of Medicine and Dentistry

ABSTRACT: Barts and The London School of Medicine and Dentistry

PROVIDER: EGAO00000000033 | EGA |

REPOSITORIES: EGA

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Multiple common variants for celiac disease influencing immune gene expression.

Dubois Patrick C A PC   Trynka Gosia G   Franke Lude L   Hunt Karen A KA   Romanos Jihane J   Curtotti Alessandra A   Zhernakova Alexandra A   Heap Graham A R GA   Adány Róza R   Aromaa Arpo A   Bardella Maria Teresa MT   van den Berg Leonard H LH   Bockett Nicholas A NA   de la Concha Emilio G EG   Dema Bárbara B   Fehrmann Rudolf S N RS   Fernández-Arquero Miguel M   Fiatal Szilvia S   Grandone Elvira E   Green Peter M PM   Groen Harry J M HJ   Gwilliam Rhian R   Houwen Roderick H J RH   Hunt Sarah E SE   Kaukinen Katri K   Kelleher Dermot D   Korponay-Szabo Ilma I   Kurppa Kalle K   MacMathuna Padraic P   Mäki Markku M   Mazzilli Maria Cristina MC   McCann Owen T OT   Mearin M Luisa ML   Mein Charles A CA   Mirza Muddassar M MM   Mistry Vanisha V   Mora Barbara B   Morley Katherine I KI   Mulder Chris J CJ   Murray Joseph A JA   Núñez Concepción C   Oosterom Elvira E   Ophoff Roel A RA   Polanco Isabel I   Peltonen Leena L   Platteel Mathieu M   Rybak Anna A   Salomaa Veikko V   Schweizer Joachim J JJ   Sperandeo Maria Pia MP   Tack Greetje J GJ   Turner Graham G   Veldink Jan H JH   Verbeek Wieke H M WH   Weersma Rinse K RK   Wolters Victorien M VM   Urcelay Elena E   Cukrowska Bozena B   Greco Luigi L   Neuhausen Susan L SL   McManus Ross R   Barisani Donatella D   Deloukas Panos P   Barrett Jeffrey C JC   Saavalainen Paivi P   Wijmenga Cisca C   van Heel David A DA  

Nature genetics 20100228 4

We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P(combined) < 5 x 10(-8)); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 h  ...[more]

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