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Dataset Information

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ICGC


ABSTRACT: Organisation EGAO00000000035

PROVIDER: EGAO00000000035 | EGA |

REPOSITORIES: EGA

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Publications

Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer.

Bova G Steven GS   Kallio Heini M L HM   Annala Matti M   Kivinummi Kati K   Högnäs Gunilla G   Häyrynen Sergei S   Rantapero Tommi T   Kivinen Virpi V   Isaacs William B WB   Tolonen Teemu T   Nykter Matti M   Visakorpi Tapio T  

Cold Spring Harbor molecular case studies 20160501 3


We report the first combined analysis of whole-genome sequence, detailed clinical history, and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). Whole-genome and transcriptome sequence was obtained from nine anatomically separate metastases, and targeted DNA sequencing was performed in cancerous and noncancerous foci within the primary tumor specimen removed 5 yr before death. Transcriptome analysis revealed increased expression of androgen receptor (AR)-re  ...[more]

Publication: 1/18

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