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Dataset Information

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The University of Hong Kong Department of Pathology and Pfizer Inc.


ABSTRACT: Organisation EGAO00000000037

PROVIDER: EGAO00000000037 | EGA |

REPOSITORIES: EGA

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Publications


<h4>Objective</h4>Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.<h4>Design</h4>We established paired cancer (n=32) and normal organoids (n=18) from 20 patients enriched in microsatellite-stable EOCRC. Exome and transcriptome analysis was performed.<h4>Results</h4>We observed a striking diversity of molecular phenotypes, includin  ...[more]

Publication: 1/2

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