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Division of Genetics and Molecular Medicine, King's College London, London, UK

ABSTRACT: Organisation EGAO00000000053

PROVIDER: EGAO00000000053 | EGA |

REPOSITORIES: EGA

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Publications

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Strange Amy A Capon Francesca F Spencer Chris C A CC Knight Jo J Weale Michael E ME Allen Michael H MH Barton Anne A Band Gavin G Bellenguez Céline C Bergboer Judith G M JG Blackwell Jenefer M JM Bramon Elvira E Bumpstead Suzannah J SJ Casas Juan P JP Cork Michael J MJ Corvin Aiden A Deloukas Panos P Dilthey Alexander A Duncanson Audrey A Edkins Sarah S Estivill Xavier X Fitzgerald Oliver O Freeman Colin C Giardina Emiliano E Gray Emma E Hofer Angelika A Hüffmeier Ulrike U Hunt Sarah E SE Irvine Alan D AD Jankowski Janusz J Kirby Brian B Langford Cordelia C Lascorz Jesús J Leman Joyce J Leslie Stephen S Mallbris Lotus L Markus Hugh S HS Mathew Christopher G CG McLean W H Irwin WH McManus Ross R Mössner Rotraut R Moutsianas Loukas L Naluai Asa T AT Nestle Frank O FO Novelli Giuseppe G Onoufriadis Alexandros A Palmer Colin N A CN Perricone Carlo C Pirinen Matti M Plomin Robert R Potter Simon C SC Pujol Ramon M RM Rautanen Anna A Riveira-Munoz Eva E Ryan Anthony W AW Salmhofer Wolfgang W Samuelsson Lena L Sawcer Stephen J SJ Schalkwijk Joost J Smith Catherine H CH Ståhle Mona M Su Zhan Z Tazi-Ahnini Rachid R Traupe Heiko H Viswanathan Ananth C AC Warren Richard B RB Weger Wolfgang W Wolk Katarina K Wood Nicholas N Worthington Jane J Young Helen S HS Zeeuwen Patrick L J M PL Hayday Adrian A Burden A David AD Griffiths Christopher E M CE Kere Juha J Reis André A McVean Gilean G Evans David M DM Brown Matthew A MA Barker Jonathan N JN Peltonen Leena L Donnelly Peter P Trembath Richard C RC

Nature genetics 20101017 11

To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). W ...[more]

PMID: 20953190

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Project description:BackgroundThe professional development of under-represented faculty may be enhanced by mentorship, but we understand very little about the mechanisms by which mentoring brings about change. Our study posed the research question, what are the mechanisms by which mentoring may support professional development in under-represented groups? The study aims to: (i) to pilot a mentoring scheme for female academics; (ii) to compare various health-related and attitudinal measures in mentees at baseline, 6 months, and 1 year into the mentoring relationship and, (iii) to compare pre-mentoring expectations to outcomes at 6 months and 1 year follow-up for mentees and mentors.MethodsFemale academic mentees were matched 1:1 or 2:1 with more senior academic mentors. Online surveys were conducted to compare health-related and attitudinal measures and expectations of mentoring at baseline with outcomes at 6 months and 1 year using paired t-tests and McNemar's test for matched cohort data.ResultsN = 46 mentoring pairs, 44 (96%) mentees completed the pre-mentoring survey, 37 (80%) at 6 months and 30 (65%) at 1 year. Job-related well-being (anxiety-contentment), self-esteem and self-efficacy all improved significantly and work-family conflict diminished at 1 year. Highest expectations were career progression (39; 89%), increased confidence (38; 87%), development of networking skills (33; 75%), better time-management (29; 66%) and better work-life balance (28; 64%). For mentees, expectations at baseline were higher than perceived achievements at 6 months or 1 year follow-up. For mentors (N = 39), 36 (92%) completed the pre-mentoring survey, 32 (82%) at 6 months and 28 (72%) at 1 year. Mentors' highest expectations were of satisfaction in seeing people progress (26; 69%), seeing junior staff develop and grow (19; 53%), helping solve problems (18; 50%), helping women advance their careers (18; 50%) and helping remove career obstacles (13; 36%). Overall, gains at 6 months and 1 year exceeded pre-mentoring expectations.ConclusionsThis uncontrolled pilot study suggests that mentoring can improve aspects of job-related well-being, self-esteem and self-efficacy over 6 months, with further improvements seen after 1 year for female academics. Work-family conflict can also diminish. Despite these gains, mentees' prior expectations were shown to be unrealistically high, but mentors' expectations were exceeded.

Dataset Information

Division of Genetics and Molecular Medicine, King's College London, London, UK

Publications

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

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