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ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD006006
PROVIDER: EGAO00000000078 | EGA |
REPOSITORIES: EGA
Publications
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Peifer Martin M Fernández-Cuesta Lynnette L Sos Martin L ML George Julie J Seidel Danila D Kasper Lawryn H LH Plenker Dennis D Leenders Frauke F Sun Ruping R Zander Thomas T Menon Roopika R Koker Mirjam M Dahmen Ilona I Müller Christian C Di Cerbo Vincenzo V Schildhaus Hans-Ulrich HU Altmüller Janine J Baessmann Ingelore I Becker Christian C de Wilde Bram B Vandesompele Jo J Böhm Diana D Ansén Sascha S Gabler Franziska F Wilkening Ines I Heynck Stefanie S Heuckmann Johannes M JM Lu Xin X Carter Scott L SL Cibulskis Kristian K Banerji Shantanu S Getz Gad G Park Kwon-Sik KS Rauh Daniel D Grütter Christian C Fischer Matthias M Pasqualucci Laura L Wright Gavin G Wainer Zoe Z Russell Prudence P Petersen Iver I Chen Yuan Y Stoelben Erich E Ludwig Corinna C Schnabel Philipp P Hoffmann Hans H Muley Thomas T Brockmann Michael M Engel-Riedel Walburga W Muscarella Lucia A LA Fazio Vito M VM Groen Harry H Timens Wim W Sietsma Hannie H Thunnissen Erik E Smit Egbert E Heideman Daniëlle A M DA Snijders Peter J F PJ Cappuzzo Federico F Ligorio Claudia C Damiani Stefania S Field John J Solberg Steinar S Brustugun Odd Terje OT Lund-Iversen Marius M Sänger Jörg J Clement Joachim H JH Soltermann Alex A Moch Holger H Weder Walter W Solomon Benjamin B Soria Jean-Charles JC Validire Pierre P Besse Benjamin B Brambilla Elisabeth E Brambilla Christian C Lantuejoul Sylvie S Lorimier Philippe P Schneider Peter M PM Hallek Michael M Pao William W Meyerson Matthew M Sage Julien J Shendure Jay J Schneider Robert R Büttner Reinhard R Wolf Jürgen J Nürnberg Peter P Perner Sven S Heukamp Lukas C LC Brindle Paul K PK Haas Stefan S Thomas Roman K RK
Nature genetics 20120902 10
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million base pairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases, we found evidence for inactivation of TP53 and RB1 and identified recurrent mutations in the CREBBP, EP300 and MLL ...[more]
Similar Datasets
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