Dataset Information
Barts Cancer Institute
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000123 | EGA |
REPOSITORIES: EGA
Publications
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Nature genetics 20151221 2
Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. Although frequent gene mutations in key signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typically overlaps with that in the closely related diffuse large B cell lymphoma (DLBCL). Using a combination of discovery exome and extended targeted sequencing, we identified recurrent somatic mutations in R ...[more]