Harvard School of Public Health
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: E-MTAB-1425
PROVIDER: EGAO00000000131 | EGA |
REPOSITORIES: EGA
Publications
A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.
Liang Liming L Morar Nilesh N Dixon Anna L AL Lathrop G Mark GM Abecasis Goncalo R GR Moffatt Miriam F MF Cookson William O C WO
Genome research 20130123 4
Gene expression levels can be an important link DNA between variation and phenotypic manifestations. Our previous map of global gene expression, based on ~400K single nucleotide polymorphisms (SNPs) and 50K transcripts in 400 sib pairs from the MRCA family panel, has been widely used to interpret the results of genome-wide association studies (GWASs). Here, we more than double the size of our initial data set with expression data on 550 additional individuals from the MRCE family panel using the ...[more]
Similar Datasets
Project description:Organisation EGAO00000000973
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Project description:Organisation EGAO00000001157
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Project description:SARS CoV-2 WGS (Georgia Department of Public Health)
| PRJNA713775 | ENA
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Project description:BackgroundAs concern about youth obesity continues to mount, there is increasing consideration of widespread policy changes to support improved nutritional and enhanced physical activity offerings in schools. A critical element in the success of such programs may be to involve students as spokespeople for the program. Making such a public commitment to healthy lifestyle program targets (improved nutrition and enhanced physical activity) may potentiate healthy behavior changes among such students and provide a model for their peers. This paper examines whether student's "public commitment"--voluntary participation as a peer communicator or in student-generated media opportunities--in a school-based intervention to prevent diabetes and reduce obesity predicted improved study outcomes including reduced obesity and improved health behaviors.MethodsSecondary analysis of data from a 3-year randomized controlled trial conducted in 42 middle schools examining the impact of a multi-component school-based program on body mass index (BMI) and student health behaviors. A total of 4603 students were assessed at the beginning of sixth grade and the end of eighth grade. Process evaluation data were collected throughout the course of the intervention. All analyses were adjusted for students' baseline values. For this paper, the students in the schools randomized to receive the intervention were further divided into two groups: those who participated in public commitment activities and those who did not. Students from comparable schools randomized to the assessment condition constituted the control group.ResultsWe found a lower percentage of obesity (greater than or equal to the 95th percentile for BMI) at the end of the study among the group participating in public commitment activities compared to the control group (21.5% vs. 26.6%, p = 0.02). The difference in obesity rates at the end of the study was even greater among the subgroup of students who were overweight or obese at baseline; 44.6% for the "public commitment" group, versus 53.2% for the control group (p = 0.01). There was no difference in obesity rates between the group not participating in public commitment activities and the control group (26.4% vs. 26.6%).ConclusionsParticipating in public commitment activities during the HEALTHY study may have potentiated the changes promoted by the behavioral, nutrition, and physical activity intervention components.Trial registrationClinicalTrials.gov number, NCT00458029.
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Project description:Organisation EGAO00000001067
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