Dataset Information
University of Cambridge & Cancer Research UK Cambridge Institute
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000147 | EGA |
REPOSITORIES: EGA
Publications
The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.
Molecular cell 20140227 5
Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing the transformation of cells in vitro and potentiating tumor formation and metastatic features in vivo. We identify an inverse correlation between EMSY amplification and miR-31 expression, an antimetastatic microRNA, in the METABRIC cohort of human ...[more]
