Dataset Information
BC CANCER RESEARCH CENTRE (BCCRC)
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000160 | EGA |
REPOSITORIES: EGA
Publications
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.
Nature 20151202 7581
Most human breast cancers have diversified genomically and biologically by the time they become clinically evident. Early events involved in their genesis and the cellular context in which these events occur have thus been difficult to characterize. Here we present the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, ...[more]
