Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000215 | EGA |
REPOSITORIES: EGA
Shiozawa Yusuke Y Malcovati Luca L Gallì Anna A Pellagatti Andrea A Karimi Mohsen M Sato-Otsubo Aiko A Sato Yusuke Y Suzuki Hiromichi H Suzuki Hiromichi H Yoshizato Tetsuichi T Yoshida Kenichi K Yoshida Kenichi K Shiraishi Yuichi Y Chiba Kenichi K Makishima Hideki H Boultwood Jacqueline J Hellström-Lindberg Eva E Miyano Satoru S Cazzola Mario M Ogawa Seishi S
Blood 20171102 24
Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic disorders with a highly variable prognosis. To identify a gene expression-based classification of myelodysplasia with biological and clinical relevance, we performed a comprehensive transcriptomic analysis of myeloid neoplasms with dysplasia using transcriptome sequencing. Unsupervised clustering of gene expression data of bone marrow CD34<sup>+</sup> cells from 100 patients identified 2 subgroups. The first subty ...[more]