Dataset Information
Leiden University Medical Center
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000220 | EGA |
REPOSITORIES: EGA
Publications
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.
Diabetologia 20140807 11
<h4>Aims/hypothesis</h4>Not all obese individuals develop type 2 diabetes. Why some obese individuals retain normal glucose tolerance (NGT) is not well understood. We hypothesise that the biochemical mechanisms that underlie the function of adipose tissue can help explain the difference between obese individuals with NGT and those with type 2 diabetes.<h4>Methods</h4>RNA sequencing was used to analyse the transcriptome of samples extracted from visceral adipose tissue (VAT) and subcutaneous adip ...[more]
