Project description:Mixed-lineage leukemias represent about 3-5% of acute leukemias occurring in patients of all ages and comprise several different subtypes (biphenotypic, bilineal, and lineage switch). The optimal therapeutic approach to these cases, especially in pediatric patients, has not been defined. We used microarrays to detail the gene expression of pediatric patients with biophenotypic leukemia. Keywords: Patient sample accumulation

2009-01-06 | GSE14286 | GEO

Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania

Project description:Organisation EGAO00000000113

| EGAO00000000113 | EGA

Children's Cancer Research Institute, Vienna

Project description:Organisation EGAO00000000355

| EGAO00000000355 | EGA

Potentially Preventable 30-Day Hospital Readmissions at a Children's Hospital.

Project description:Hospital readmission rates are increasingly used to assess quality. Little is known, however, about potential preventability of readmissions among children. Our objective was to evaluate potential preventability of 30-day readmissions using medical record review and interviews.A cross-sectional study in 305 children (<18 years old) readmitted within 30 days to a freestanding children's hospital between December 2012 and February 2013. Interviews (N = 1459) were conducted with parents/guardians, patients (if ≥13 years old), inpatient clinicians, and primary care providers. Reviewers evaluated medical records, interview summaries, and transcripts, and then rated potential preventability. Multivariate regression analysis was used to identify factors associated with potentially preventable readmission. Adjusted event curves were generated to model days to readmission.Of readmissions, 29.5% were potentially preventable. Potentially preventable readmissions occurred sooner after discharge than non-potentially preventable readmissions (5 vs 9 median days; P < .001). The odds of a readmission being potentially preventable were greatest when the index admission and readmission were causally related (adjusted odds ratio [AOR]: 2.6; 95% confidence interval [CI]: 1.0-6.8) and when hospital (AOR: 16.3; 95% CI: 5.9-44.8) or patient (AOR: 7.1; 95% CI: 2.5-20.5) factors were identified. Interviews provided new information about the readmission in 31.2% of cases.Nearly 30% of 30-day readmissions to a children's hospital may be potentially preventable. Hospital and patient factors are associated with potential preventability and may provide targets for quality improvement efforts. Interviews contribute important information and should be considered when evaluating readmissions.

| S-EPMC5557411 | biostudies-other

Children's Hospital, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine

Project description:we adopted DIA-MS method to profile serum proteome signatures of acute asthma children and convalescent ones. As result, we identified 747 proteins were identified in 46 serum samples and detected 37 differentially expressed proteins that could clearly separate asthmatic and healthy children.

2022-04-20 | PXD033315 |

Zhongshan Hospital

Project description:Organisation EGAO00000001025

| EGAO00000001025 | EGA

Luohu Hospital

Project description:Organisation EGAO00000000718

| EGAO00000000718 | EGA