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Dataset Information

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Saarland University

ABSTRACT: Organisation EGAO00000000237

PROVIDER: EGAO00000000237 | EGA |

REPOSITORIES: EGA

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Publications

Evolutionary origin and methylation status of human intronic CpG islands that are not present in mouse.

Rademacher Katrin K   Schröder Christopher C   Kanber Deniz D   Klein-Hitpass Ludger L   Wallner Stefan S   Zeschnigk Michael M   Horsthemke Bernhard B  

Genome biology and evolution 20140612 7

Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrocopy derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrocopy and is not imprinted. We have investigated whether the RB1/Rb1 locus is unique with respect to these differences. For this, we have compared the CGIs from human and mouse by in silico analyses. We have found that the human genome does not only contain more C  ...[more]

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