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Dataset Information

1K

KCL-CS


ABSTRACT: Organisation EGAO00000000248

PROVIDER: EGAO00000000248 | EGA |

REPOSITORIES: EGA

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Publications


Hepatocellular carcinoma (HCC) is almost invariably associated with an underlying inflammatory state, whose direct contribution to the acquisition of critical genomic changes is unclear. Here we map acquired genomic alterations in human and mouse HCCs induced by defects in hepatocyte biliary transporters, which expose hepatocytes to bile salts and cause chronic inflammation that develops into cancer. In both human and mouse cancer genomes, we find few somatic point mutations with no impairment o  ...[more]

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