Dataset Information
Hospital Sant Joan de Deu, Barcelona
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000258 | EGA |
REPOSITORIES: EGA
Publications
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.
Nature genetics 20140406 5
Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations in ...[more]