Browse
Submit Data
Databases
API
Help

Dataset Information

13 Views

141 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 1004

University Medical Centre Groningen

ABSTRACT: Organisation EGAO00000000286

PROVIDER: EGAO00000000286 | EGA |

REPOSITORIES: EGA

ACCESS DATA

Json Xml

Publications

Evaluation of European coeliac disease risk variants in a north Indian population.

Senapati Sabyasachi S Gutierrez-Achury Javier J Sood Ajit A Midha Vandana V Szperl Agata A Romanos Jihane J Zhernakova Alexandra A Franke Lude L Alonso Santos S Thelma B K BK Wijmenga Cisca C Trynka Gosia G

European journal of human genetics : EJHG 20140723 4

Studies in European populations have contributed to a better understanding of the genetics of complex diseases, for example, in coeliac disease (CeD), studies of over 23 000 European samples have reported association to the HLA locus and another 39 loci. However, these associations have not been evaluated in detail in other ethnicities. We sought to better understand how disease-associated loci that have been mapped in Europeans translate to a disease risk for a population with a different ethni ...[more]

PMID: 25052311

Similar Datasets

Columbia University Medical Centre

Project description:Organisation EGAO00000000913

| EGAO00000000913 | EGA

Queensland Centre for Medical Genomics, University of Queensland

Project description:Organisation EGAO00000000249

| EGAO00000000249 | EGA

Outcome of mechanical circulatory support at the University Medical Centre Utrecht.

Project description:BACKGROUND:The prevalence of heart failure (HF) is increasing substantially and, despite improvements in medical therapy, HF still carries a poor prognosis. Mechanical circulatory support (MCS) by a continuous-flow left ventricular assist device (cf-LVAD) improves survival and quality of life in selected patients. This holds especially for the short-term outcome, but experience regarding long-term outcome is growing as the waiting time for heart transplantation is increasing due to the shortage of donor hearts. Here we present our results from the University Medical Centre Utrecht. METHODS:Data of all patients with a cf-LVAD implant between March 2006 and January 2018 were collected. The primary outcome was survival. Secondary outcomes included adverse events defined according to the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions, described per patient year. RESULTS:A total of 268 patients (69% male, mean age 50?±?13 years) received a cf-LVAD. After a median follow-up of 542 (interquartile range 205-1044) days, heart transplantation had been performed in 82 (31%) patients, the cf-LVAD had been explanted in 8 (3%) and 71 (26%) had died. Survival at 1, 3 and 5 years was 83%, 72% and 57%, respectively, with heart transplantation, cf-LVAD explantation or death as the end-point. Death was most often caused by neurological complications (31%) or infection (20%). Major bleeding occurred 0.51 times and stroke 0.15 times per patient year. CONCLUSION:Not only short-term results but also 5?year survival after cf-LVAD support demonstrate that MCS is a promising therapy as an extended bridge to heart transplantation. However, the incidence of several major complications still has to be addressed.

| S-EPMC7113343 | biostudies-literature

Columbia University Irving Medical Center RNASeq of meningioma tumors

Project description:We use a Master Regular-based precision cancer medicine framework to predict drug sensitivity to tumors.

2022-09-06 | GSE212377 | GEO

Twelve years of circulatory extracorporeal life support at the University Medical Centre Utrecht.

Project description:IntroductionCirculatory extracorporeal life support (ECLS) has been performed at the University Medical Centre Utrecht for 12 years. During this time, case mix, indications, ECLS set-ups and outcomes seem to have substantially changed. We set out to describe these characteristics and their evolution over time.MethodsAll patients receiving circulatory ECLS between 2007 and 2018 were retrospectively identified and divided into six groups according to a 2-year period of time corresponding to the date of ECLS initiation. General characteristics plus data pertaining to comorbidities, indications and technical details of ECLS commencement as well as in-hospital, 30-day, 1‑year and overall mortality were collected. Temporal trends in these characteristics were examined.ResultsA total of 347 circulatory ECLS runs were performed in 289 patients. The number of patients and ECLS runs increased from 8 till a maximum of 40 runs a year. The distribution of circulatory ECLS indications shifted from predominantly postcardiotomy to a wider set of indications. The proportion of peripheral insertions with or without application of left ventricular unloading techniques substantially increased, while in-hospital, 30-day, 1‑year and overall mortality decreased over time.ConclusionCirculatory ECLS was increasingly applied at the University Medical Centre Utrecht. Over time, indications as well as treatment goals broadened, and cannulation techniques shifted from central to mainly peripheral approaches. Meanwhile, weaning success increased and mortality rates diminished.

| S-EPMC8271054 | biostudies-literature

Erasmus Medical Centre, department Hematology

Project description:Organisation EGAO00000000226

| EGAO00000000226 | EGA

Nanjing Medical University

Project description:Organisation EGAO00000001266

| EGAO00000001266 | EGA

Shanxi Medical University

Project description:Organisation EGAO00000000642

| EGAO00000000642 | EGA

Erasmus University Medical Center

Project description:Organisation EGAO00000001053