Dataset Information

Duke-NUS Graduate Medical School Singapore

ABSTRACT: Organisation EGAO00000000315

PROVIDER: EGAO00000000315 | EGA |

REPOSITORIES: EGA

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Publications

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul Apinya A Cutcutache Ioana I Yong Chern Han CH Lim Jing Quan JQ Huang Mi Ni MN Padmanabhan Nisha N Nellore Vishwa V Kongpetch Sarinya S Ng Alvin Wei Tian AWT Ng Ley Moy LM Choo Su Pin SP Myint Swe Swe SS Thanan Raynoo R Nagarajan Sanjanaa S Lim Weng Khong WK Ng Cedric Chuan Young CCY Boot Arnoud A Liu Mo M Ong Choon Kiat CK Rajasegaran Vikneswari V Lie Stefanus S Lim Alvin Soon Tiong AST Lim Tse Hui TH Tan Jing J Loh Jia Liang JL McPherson John R JR Khuntikeo Narong N Bhudhisawasdi Vajaraphongsa V Yongvanit Puangrat P Wongkham Sopit S Totoki Yasushi Y Nakamura Hiromi H Arai Yasuhito Y Yamasaki Satoshi S Chow Pierce Kah-Hoe PK Chung Alexander Yaw Fui AYF Ooi London Lucien Peng Jin LLPJ Lim Kiat Hon KH Dima Simona S Duda Dan G DG Popescu Irinel I Broet Philippe P Hsieh Sen-Yung SY Yu Ming-Chin MC Scarpa Aldo A Lai Jiaming J Luo Di-Xian DX Carvalho André Lopes AL Vettore André Luiz AL Rhee Hyungjin H Park Young Nyun YN Alexandrov Ludmil B LB Gordân Raluca R Rozen Steven G SG Shibata Tatsuhiro T Pairojkul Chawalit C Teh Bin Tean BT Tan Patrick P

Cancer discovery 20170630 10

Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clustering defined 4 CCA clusters-fluke-positive CCAs (clusters 1/2) are enriched in <i>ERBB2</i> amplifications and <i>TP53</i> mutations; conversely, fluke-negative CCAs (clusters 3/4) exhibit high copy ...[more]

PMID: 28667006

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Project description:Defining professionalism in this constantly evolving world is not easy. How do you measure degrees of benevolence and compassion? If it is so obvious to our profession, what professionalism is, then why is it so difficult to teach it to medical students and residents? Today's definition of medical professionalism is evolving - from autonomy to accountability, from expert opinion to evidence-based medicine, and from self-interest to teamwork and shared responsibility. However, medical professionalism is defined as the basis for the trust in the patient-physician relationship, caring and compassion, insight, openness, respect for patient dignity, confidentiality, autonomy, presence, altruism, and those qualities that lead to trust-competence, integrity, honesty, morality, and ethical conduct. The purpose of this study is to explore professionalism in terms of its fundamental elements among medical students of Universiti Sultan Zainal Abidin (UniSZA). This was a cross-sectional study carried out on medical students of UniSZA. The study population included preclinical and clinical medical students of UniSZA from Year I to Year V of academic session 2014/2015. The simple random sampling technique was used to select the sample. Data were collected using a validated instrument. The data were then compiled and analyzed using SPSS Version 21. Out of 165 questionnaires distributed randomly among Year I to Year V medical students of UniSZA, 144 returned, giving a response rate of 87%. Among the study participants, 38% (54) and 62% (90) were males and females, respectively. The grand total score was 170.92±19.08. A total of 166.98±20.15 and 173.49±18.09 were the total professionalism score of male and female study participants, respectively, with no statistically significant (P=0.61) differences. This study found almost similar levels of familiarity with all fundamental issues of professionalism with no statistically (P>0.05) significant differences. Medical faculty members should give more effort for the professional development of medical doctor. Henceforth, researchers believe and expect that the country will produce more rational and holistic medical doctors.

Dataset Information

Duke-NUS Graduate Medical School Singapore

Publications

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

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